Web Table 1. Values of mean arterial pressure (MAP; mm Hg) at the indicated time points

 

 

 

Preoperative visit

 

Premedication

 

Before induction

 

Before laryngoscopy

 

During laryngoscopy

 

Before tracheal intubation

 

Two minutes after tracheal intubation

 

Before skin incision

 

Two minutes after skin incision

 

Group 1

 

n = 21

93 (11)

93

[70-118]

 

 

n = 21

103 (15)

102

[81-144]

 

n = 21

106 (17)

104

[83-157]

 

 

n = 21

75 (14)

75

[59-120]

 

 

n = 21

93 (22)

87

[61-131]

 

 

n = 21

98 (22)

95

[59-139]

 

 

n = 21

87 (13)

87

[67-114]

 

 

n = 21

75 (10)

76

[57-95]

 

 

n = 21

89 (17)

87

[64-131]

 

Group 2

 

n = 22

95 (13)

93

[73-127]

 

 

n = 22

102 (16)

101

[74-130]

 

n = 22

104 (16)

106

[78-131]

 

 

n = 22

80 (19)

85

[42-114]

 

 

n = 22

92 (26)

91

[48-137]

 

 

n = 22

90 (25)

87

[55-156]

 

 

n = 22

88 (21)

92

[41-121]

 

 

n = 22

78 (12)

77

[50-104]

 

 

n = 22

89 (15)

88

[64-119]

 

Group 3

 

n = 23

91 (15)

89

[73-139]

 

n = 23

101 (19)

100

[66-143]

 

 

n = 23

97 (18)

96

[58-143]

 

 

n = 22

75 (15)

72.5

[52-120]

 

 

n = 22

78 (18)

76

[50-120]

 

 

n = 22

86 (25)

79

[53-130]

 

 

n = 23

82 (15)

80

[58-118]

 

 

n = 23

77 (13)

75

[57-109]

 

 

n = 23

86 (12)

84

[62-111]

 

Group 4

 

n = 20

95 (10)

95

[77-119]

 

 

n = 21

102 (14)

101

[81-146]

 

 

n = 21

102 (14)

101

[81-135]

 

n = 20

74 (19)

71

[45-130]

 

 

n = 21

78 ( 23)

76

[46-131]

 

 

n = 21

80 ( 22)

77

[48-143]

 

 

n = 21

80 (16)

76

[51-111]

 

 

n = 21

76 (14)

73

[45-99]

 

 

n = 21

78 (16)

76

[49-110]

 

Group 5

 

n = 23

93 (11)

93

[75-117]

 

n = 22

104 (12)

104

[74-121]

 

 

n = 23

104 (10)

105

[81-124]

 

 

n = 23

76 (16)

71

[57-123]

 

 

n = 23

80 (20)

75

[55-123]

 

 

n = 23

79 (16)

75

[62-122]

 

 

n = 23

80 (17)

77

[56-130]

 

 

n = 22

78 (12)

78

[58-110]

 

 

n = 21

83 (11)

84

[61-107]

 

 

Legend to Web Table 1. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA; p = 0.34) and there was no group versus time interaction (p = 0.34).

 


 

Web Table 2. Values of mean arterial pressure (MAP; mm Hg) at the indicated time points

 

 

Before sternotomy

Two minutes after sternotomy

Aortic cannulation

Two minutes before CPB onset

Two minutes after CPB onset

Ten minutes after protamine

Sternal closure

Skin closure

Two hours after arrival in the ICU

Onset of spontaneous ventilation

Five minutes after tracheal extubation

Group

1

n = 21

92 (16)

89

[64-130]

n = 21

95 (13)

93

[76-124]

n = 21

86 (15)

85

[61-120]

n = 21

78 (9)

77

[64-95]

n = 21

69 (14)

69

[45-101]

n = 21

77 (12)

77

[54-114]

n = 21

79 (8)

79

[66-97]

n = 21

80 (12)

81

[55-98]

n = 21

79 (15)

76

[51-111]

n = 21

88 (18)

87

[55-142]

n = 21

87 (12)

89

[69-111]

Group 2

n = 22

92 (12)

93

[71-120]

n = 22

95 (10)

94

[75-123]

n = 22

83 (12)

86

[56-104]

n = 22

78 (14)

74

[61-101]

n = 21

66 (14)

63

[45-103]

n = 22

82 (12)

83

[61-102]

n = 22

81 (10)

81

[63-103]

n = 21

80 (12)

77

[58-101]

n = 22

81 (13)

82

[64-120]

n = 22

88 (13)

88

[62-110]

n = 22

87 ( 11)

87

[68-116]

Group 3

n = 23

90 (13)

89

[72-118]

n = 23

91 (15)

91

[63-130]

n = 23

84 (10)

85

[67-106]

n = 23

76 (11)

75

[59-96]

n = 23

74 (18)

77

[33-100]

n = 23

72 (9)

72

[55-96]

n = 23

74 (8)

72

[60-97]

n = 23

75 (8)

75

[63-90]

n = 23

78 (11)

79

[54-100]

n = 23

86 (12)

86

[61-110]

n = 23

87 (11)

86

[68-107]

Group 4

n = 21

86 (10)

87

[64-110]

n = 21

90 (11)

94

[69-112]

n = 21

83 (13)

85

[55-108]

n = 21

74 (14)

77

[39-97]

n = 20

68 (20)

74

[38-112]

n = 21

74 (12)

72

[61-105]

n = 21

74 (12)

74

[50-106]

n = 21

76 (10)

72

[67-105]

n = 21

77 (14)

74

[58-106]

n = 21

82 (10)

81

[67-98]

n = 21

82 (12)

81

[63-104]

Group 5

n = 22

85 (10)

84

[63-116]

n = 22

90 (14)

87

[72-124]

n = 22

88 (17)

85

[67-143]

n = 22

78 (13)

77

[52-99]

n = 21

72 (16)

75

[41-95]

n = 22

74 (12)

73

[53-97]

n = 22

77 (13)

75

[50-103]

n = 22

75 (10)

71

[61-97]

n = 21

80 (14)

79

[63-117]

n = 22

85 (12)

83

[65-114]

n = 22

85 (12)

84

[60-112]

 

 

Legend to Web Table 2. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA; p = 0.34) and there was no group versus time interaction (p = 0.34).


Web Table 3. Ratio of mean arterial pressure (MAP) value at the indicated time point /to the value of MAP measured at the preoperative visit considered as baseline

 

Before induction

Before laryngoscopy

During laryngoscopy

Before tracheal intubation

Two minutes after tracheal intubation

Before skin incision

Two minutes after skin incision

Before sternotomy

Two minutes after sternotomy

Group 1

n = 21

1.15 ( 0.22)

1.07

[0.9-1.81]

n = 21

0.82 ( 0.2)

0.79

[0.59-1.38]

n = 21

1.01 ( 0.26)

0.96

[0.64-1.57]

n = 21

1.07( 0.31)

1.05

[0.61-1.67]

n = 21

0.94 ( 0.18)

0.94

[0.65-1.36]

n = 21

0.81 ( 0.17)

0.77

[0.57-1.21]

n = 21

0.96 ( 0.24)

0.91

[0.68-1.57]

n = 21

1 ( 0.23)

0.93

[0.67-1.56]

n = 21

1.03 ( 0.19)

0.98

[0.75-1.42]

Group 2

n = 22

1.1 ( 0.16)

1.07

[0.85-1.47]

n = 22

0.86 ( 0.21)

0.83

[0.43-1.27]

n = 22

0.98 ( 0.31)

1.02

[0.4-1.88]

n = 22

0.97 ( 0.29)

0.97

[0.46-1.64]

n = 22

0.95 ( 0.27)

0.89

[0.44-1.62]

n = 22

0.84 ( 0 .14)

0.87

[0.54-1.14]

n = 22

0.96 ( 0.22)

0.95

[0.53-1.4]

n = 22

0.98 ( 0.19)

1

[0.61-1.36]

n = 22

1.02 ( 0.15)

1.04

[0.73-1.32]

Group 3

n = 23

1.07 ( 0.17)

1.03

[0.78-1.53]

n = 22

0.82 ( 0.18)

0.79

[0.52-1.33]

n = 22

0.88 ( 0.26)

0.83

[0.48-1.43]

n = 22

0.95 ( 0.28)

0.92

[0.51-1.45]

n = 23

0.91 ( 0.2)

0.91

[0.51-1.34]

n = 23

0.85 ( 0.19)

0.82

[0.59-1.26]

n = 23

0.96 ( 0.19)

0.94

[0.58-1.3]

n = 23

1.01 ( 0.2)

0.99

[0.61-1.33]

n = 23

1.01 ( 0.19)

1

[0.68-1.37]

Group 4

n = 20

1.07 ( 0.11)

1.05

[0.82-1.3]

n = 19

0.76 ( 0.2)

0.75

[0.41-1.39]

n = 20

0.8 ( 0.21)

0.77

[0.45-1.27]

n = 20

0.82 ( 0.22)

0.83

[0.42-1.53]

n = 20

0.83 ( 0.15)

0.81

[0.64-1.19]

n = 20

0.8 ( 0.18)

0.77

[0.48-1.13]

n = 20

0.82 ( 0.21)

0.76

[0.53-1.27]

n = 20

0.91 ( 0.17)

0.88

[0.64-1.27]

n = 20

0.96 ( 0.17)

0.96

[0.61-1.29]

Group 5

n = 23

1.13 ( 0.16)

1.1

[0.85-1.49]

n = 23

0.81 ( 0.11)

0.78

[0.64-1.05]

n = 23

0.85 ( 0.16)

0.83

[0.62-1.18]

n = 23

0.85 ( 0.16)

0.85

[0.63-1.3]

n = 23

0.86 ( 0.17)

0.86

[0.62-1.33]

n = 22

0.85 ( 0.17)

0.83

[0.58-1.22]

n = 21

0.91 ( 0.16)

0.89

[0.66-1.19]

n = 22

0.93 ( 0.18)

0.9

[0.68-1.29]

n = 22

0.98 ( 0.19)

0.95

[0.71-1.41]

 

Legend to Web Table 3. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA) and there was no group versus time interaction.


 

Web Table 4 . Ratio of mean arterial pressure (MAP) value at the indicated time point /to the value of MAP measured at the preoperative visit considered as baseline

 

Aortic cannulation

Two minutes before CPB onset

Two minutes after CPB onset

Ten minutes after protamine

Sternal closure

Skin closure

Two hours after arrival in the ICU

Onset of spontaneous ventilation

 

Five minutes after tracheal extubation

 

Group 1

 

n = 21

0.93 (0.18)

0.89

[0.71-1.35]

 

n = 21

0.84 (0.12)

0.81

[0.6-1.1]

 

 

n = 21

0.74 (0.16)

0.73

[0.48-1.19]

 

 

n = 21

0.83 (0.17)

0.81

[0.59-1.32]

 

 

n = 21

0.85 (0.15)

0.86

[0.56-1.19]

 

 

n = 21

0.87 (0.17)

0.83

[0.55-1.28]

 

 

n = 21

0.85 (0.16)

0.82

[0.48-1.13]

 

 

n = 21

0.96 (0.25)

0.91

[0.61-1.7]

 

 

n = 21

0.93 (0.12)

0.92

[0.78-1.15]

 

Group 2

 

n = 22

0.89 (0.19)

0.88

[0.56-1.32]

 

n = 22

0.84 (0.2)

0.79

[0.48-1.26]

 

 

n = 21

0.71 (0.19)

0.69

[0.38-1.16]

 

 

n = 22

0.88 (0.16)

0.89

[0.51-1.25]

 

 

n = 22

0.86 (0.13)

0.86

[0.65-1.29]

 

 

n = 21

0.85 (0.15)

0.82

[0.6-1.25]

 

 

n = 22

0.87 (0.15)

0.87

[0.64-1.18]

 

 

n = 22

0.93 (0.15)

0.94

[0.62-1.23]

 

 

n = 22

0.93 (0.17)

0.9

[0.68-1.28]

 

Group 3

 

n = 23

0.94 (0.18)

0.96

[0.52-1.25]

 

 

n = 23

0.86 (0.19)

0.86

[0.5-1.2]

 

 

n = 23

0.82 (0.21)

0.77

[0.38-1.29]

 

 

n = 23

0.8 (0.14)

0.8

[0.49-1.13]

 

 

n = 23

0.82 (0.13)

0.82

[0.47-1.05]

 

 

n = 23

0.83 (0.13)

0.85

[0.45-1.02]

 

 

n = 23

0.87 (0.18)

0.89

[0.57-1.28]

 

 

n = 23

0.95 (0.17)

0.92

[0.66-1.31]

 

 

n = 23

0.96 (0.13)

0.93

[0.72-1.23]

 

Group 4

 

n = 20

0.87 (0.16)

0.9

[0.63-1.16]

 

 

n = 20

0.78 (0.17)

0.83

[0.45-1.12]

 

n = 19

0.72 (0.22)

0.75

[0.32-1.08]

 

 

n = 20

0.77 (0.13)

0.75

[0.59-1.09]

 

 

n = 20

0.78 (0.15)

0.77

[0.58-1.07]

 

 

n = 20

0.8 (0.10)

0.8

[0.62-1.01]

 

 

n = 20

0.82 (0.17)

0.84

[0.54-1.12]

 

 

n = 20

0.86 (0.12)

0.85

[0.59-1.12]

 

 

n = 20

0.86 (0.12)

0.85

[0.64-1.16]

 

Group 5

 

n = 22

0.95 (0.2)

0.88

[0.7-1.39]

 

 

n = 22

0.85 (0.18)

0.81

[0.5-1.2]

 

 

n = 21

0.79 (0.2)

0.75

[0.41-1.13]

 

 

n = 22

0.81 (0.18)

0.81

[0.51-1.3]

 

 

n = 22

0.84 (0.22)

0.81

[0.54-1.29]

 

 

n = 22

0.83 (0.18)

0.84

[0.61-1.24]

 

 

n = 21

0.87 (0.17)

0.88

[0.57-1.17]

 

 

n = 22

0.92 (0.16)

0.88

[0.7-1.37]

 

 

n = 22

0.93 (0.21)

0.88

[0.65-1.34]

 

 

Legend to Web Table 4. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA) and there was no group versus time interaction

 


Web Table 5. Values of heart rate (bpm) at the indicated time-points

 

 

 

Preoperative visit

 

Premedication

 

Before induction

 

Before laryngoscopy

 

Laryngoscopy

 

Before intubation

 

Two minutes after intubation

 

Before skin incision

 

Two minutes after skin incision

 

Group 1

 

n = 21

61 (9)

60

[39-80]

 

 

n = 21

57 (8)

57

[40-74]

 

n = 21

57 (8)

57

[42-72]

 

 

n = 21

57 (9)

57

[40-75]

 

 

n = 21

60 (10)

60

[43-79]

 

 

n = 21

64 (11)

63

[46-88]

 

 

n = 21

64 (11)

65

[47-88]

 

 

n = 21

54 (8)

54

[37-75]

 

 

n = 21

56 (10)

54

[37-80]

 

Group 2

 

n = 22

62 (9)

61

[43-80]

 

 

n = 22

58 (11)

56

[43-101]

 

n = 22

58 (9)

58

[43-91]

 

 

n = 22

57 (12)

57

[44-93]

 

 

n = 22

58 (12)

57.5

[44-88]

 

 

n = 22

61 (13)

59

[42-94]

 

 

n = 22

63 (11)

61.5

[45-86]

 

 

n = 22

55 (9)

53.5

[40-75]

 

 

n = 22

56 (10)

56

[40-77]

 

Group 3

 

n = 23

64 (9)

60

[49-80]

 

 

n = 23

60 (9)

60

[48-74]

 

 

n = 23

62 (10)

62

[46-82]

 

 

n = 22

58 (9)

57.5

[42-78]

 

 

n = 22

58 (9)

61

[39-77]

 

 

n = 23

61 (9)

63

[48-81]

 

 

n = 23

64 (10)

65

[48-90]

 

 

n = 23

57 (8)

58

[42-75]

 

 

n = 23

62 (12)

60

[44-90]

 

Group 4

 

n = 20

62 (10)

61

[46-86]

 

 

n = 21

59 (8)

59

[46-77]

 

 

n = 21

59 (8)

60

[47-77]

 

 

n = 19

57 (10)

54

[45-86]

 

 

n = 20

57(10)

54

[45-89]

 

 

n = 21

58 (10)

56

[45-88]

 

 

n = 21

60 (9)

59

[48-84]

 

 

n = 21

56 (10)

55

[42-80]

 

 

n = 21

56 (8)

56

[42-72]

 

Group 5

 

n = 22

63 (8)

65

[48-77]

 

 

n = 23

63 (12)

62

[44-101]

 

 

n = 23

63 (11)

61

[44-103]

 

 

n = 23

62 (12)

63

[44-94]

 

 

n = 23

63 (15)

63

[44-107]

 

 

n = 23

62 (12)

64

[42-89]

 

 

n = 23

65 (12)

66

[42-95]

 

 

n = 22

58 (11)

56

[42-84]

 

 

n = 22

58 (11)

56

[45-84]

 

 

Legend to Web Table 5. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA; p = 0.91) and there was no group versus time interaction (p = 0.79).

 


 

 

Web Table 6. Values of heart rate (bpm) at the indicated time-points

 



Before sternotomy

Two minutes after sternotomy

Aortic cannulation

Two minutes before CPB onset

Ten minutes after protamine

Sternal closure

Skin closure

Two hours after arrival in the ICU

Onset of spontaneous ventilation

Five minutes after tracheal extubation

Group 1

n = 21

57 (11)

56

[37-87]

n = 21

62 (12)

61

[38-91]

n = 21

66 (15)

67

[40-98]

n = 21

69 (13)

74

[42-90]

n = 21

75 (11)

75

[42-98]

n = 21

76 (12)

76

[43-103]

n = 21

76 (11)

76

[42-92]

n = 21

75 (14)

78

[40-100]

n = 21

81 (10)

80

[69-114]

n = 21

84 (13)

86

[49-105]

Group 2

n = 22

58 (11)

57

[38-75]

n = 22

60 (12)

59

[43-85]

n = 22

62 (11)

59

[47-92]

n = 22

69 (11)

69

[ 47-85 ]

n = 22

76 (8)

78

[55-91]

n = 22

76 (11)

76

[51-98]

n = 22

74 (9)

75

[56-100]

n = 22

74 (10)

75

[56-95]

n = 22

86 (15)

85

[63-120]

n = 22

85 (12)

82

[68-110]

Group 3

n = 23

58 (10)

60

[43-79]

n = 23

63 (11)

62

[45-87]

n = 23

65 (12)

63

[47-92]

n = 23

73 (16)

73

[51-115]

n = 23

77 (9)

74

[64-98]

n = 23

77 (9)

76

[62-97]

n = 23

77 (8)

77

[60-95]

n = 23

79 (13)

78

[60-108]

n = 23

86 (10)

86

[68-110]

n = 23

88 (10)

88

[71-120]

Group 4

n = 21

58 (11)

58

[42-80]

n = 21

58 (9)

58

[45-76]

n = 21

58 (11)

54

[46-90]

n = 21

64 (9)

64

[50-86]

n = 21

77 (12)

75

[51-110]

n = 21

76 (12)

76

[48-99]

n = 21

76 (13)

77

[50-95]

n = 21

76 (14)

74

[47-101]

n = 21

83 (12)

83

[62-110]

n = 21

84 (13)

84

[55-110]

Group 5

n = 22

61 (13)

58

[45-95]

n = 22

61 (12)

64

[42-86]

n = 22

65 (14)

63

[44-95]

n = 22

75 (16)

71

[52-105]

n = 22

80 (12)

80

[48-112]

n = 22

81 (11)

80

[60-114]

n = 21

79 (12)

77

[56-113]

n = 22

81 (16)

80

[52-125]

n = 22

87 (16)

86

[60-120]

n = 22

88 (15)

85

[63-113]

 

Legend to Web Table 6. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA; p = 0.91) and there was no group versus time interaction (p = 0.79).


Web Table 7. Ratio of heart rate (HR) measured at the indicated time point/ value of HR measured at the preoperative visit considered as baseline

 

 

Before

induction

 

Before

laryngoscopy

 

During

laryngoscopy

 

Before tracheal

intubation

 

Two minutes after tracheal intubation

 

Before skin

incision

 

Two minutes after skin incision

 

Before sternotomy

Two minutes after sternotomy

Group

1

n = 21

0.96 (0.18)

0.97

[0.65-1.38]

n = 21

0.96 (0.18)

0.98

[0.6-1.46]

n = 21

1 (0.2)

1

[0.69-1.58]

n = 21

1.08 (0.25)

1.07

[0.71-1.76]

n = 21

1.08 (0.23)

1.08

[0.68-1.76]

n = 21

0.89 (0.14)

0.91

[0.68-1.12]

n = 21

0.94 (0.18)

0.88

[0.71-1.24]

n = 21

0.95 (0.18)

1.02

[0.65-1.28]

n = 21

1.04 (0.22)

1.05

[0.73-1.53]

Group 2

n = 22

0.95 (0.16)

0.96

[0.71-1.4]

n = 22

0.92 (0.18)

0.92

[0.64-1.43]

n = 22

0.94 (0.18)

0.93

[0.65-1.47]

n = 22

0.98 (0.18)

0.99

[0.72-1.45]

n = 22

1.02 (0.16)

1.02

[0.69-1.38]

n = 22

0.89 (0 .18)

0.89

[0.58-1.2]

n = 22

0.92 (0.2)

0.92

[0.56-1.28]

n = 22

0.94 (0.2)

0.94

[0.6-1.33]

n = 22

0.98 (0.25)

0.96

[0.56-1.42]

Group

3

n = 23

0.97 (0.13)

0.97

[0.73-1.25]

n = 22

0.92 (0.13)

0.92

[0.61-1.15]

n = 22

0.93 (0.13)

0.88

[0.66-1.2]

n = 23

0.97 ( 0.17)

0.95

[0.63-1.42]

n = 23

1.01 (0.17)

0.98

[0.63-1.4]

n = 23

0.89 (0.14)

0.89

[0.59-1.19]

n = 23

0.97 (0.17)

0.96

[0.59-1.33]

n = 23

0.92 (0.15)

0.91

[0.58-1.21]

n = 23

0.98 (0.15)

0.98

[0.62-1.23]

Group

4

n = 20

0.97 (0.16)

0.94

[0.69-1.3]

n = 18

0.93 (0.17)

0.94

[0.63-1.32]

n = 19

0.92 (0.18)

0.9

[0.63-1.37]

n = 20

0.93 (0.17)

0.95

[0.67-1.35]

n = 20

0.98 (0.19)

1

[0.67-1.43]

n = 20

0.91 (0.17)

0.93

[0.66-1.27]

n = 20

0.91 (0.16)

0.92

[0.66-1.24]

n = 20

0.96 (0.21)

0.93

[0.66-1.33]

n = 20

0.94 (0.16)

0.93

[0.67-1.25]

Group

5

n = 22

0.98 (0.14)

0.96

[0.76-1.47]

n = 22

0.97 (0.17)

0.94

[0.68-1.45]

n = 22

0.99 (0.21)

0.96

[0.63-1.53]

n = 22

0.97 (0.17)

0.97

[0.63-1.48]

n = 22

1.01 (0.17)

1.04

[0.72-1.39]

n = 21

0.91 (0.10)

0.92

[0.64-1.11]

n = 21

0.91 (0.11)

0.9

[0.6-1.14]

n = 21

0.94 (0.12)

0.94

[0.7-1.25]

n = 21

0.95 (0.15)

0.94

[0.72-1.43]

 

 

Legend to Web Table 7. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA) and there was no group versus time interaction .


 

Web Table 8. Ratio of heart rate (HR) measured at the indicated time point/ value of HR measured at the preoperative visit considered as baseline

 

 

 

Aortic

cannulation

 

Two minutes before CPB onset

 

Ten minutes after protamine

 

Sternal closure

 

Skin closure

 

Two hours after arrival in the ICU

 

Onset of spontaneous ventilation

 

Five minutes after tracheal intubation

Group

1

 

n = 21

1.1 (0.28)

1.06

[0.67-1.96]

 

n = 21

1.15 (0.24)

1.11

[0.81-1.67]

 

 

n = 21

1.25 (0.2)

1.25

[0.84-1.78]

 

 

n = 21

1.27 (0.18)

1.25

[1.05-1.8]

 

 

n = 21

1.26 (0.18)

1.25

[0.97-1.68]

 

 

n = 21

1.25 (0.21)

1.26

[0.73-1.7]

 

 

n = 21

1.35 (0.23)

1.32

[1.08-1.9]

 

 

n = 21

1.4 (0.23)

1.35

[1.07-2]

 

Group

2

 

n = 22

1.01 (0.24)

0.99

[0.65-1.67]

 

n = 22

1.12 (0.25)

1.11

[0.78-1.86]

 

 

n = 22

1.24 (0.23)

1.23

[0.84-1.79]

 

 

n = 22

1.25 (0.23)

1.3

[0.78-1.72]

 

n = 22

1.2 (0.23)

1.24

[0.79-1.72]

 

 

n = 22

1.21 (0.22)

1.24

[0.7-1.58]

 

 

n = 22

1.39 (0.28)

1.43

[0.79-2]

 

 

n = 22

1.39 (0.25)

1.45

[0.94-1.73]

 

Group

3

 

n = 23

1.03 (0.19)

0.98

[0.68-1.41]

 

 

n = 23

1.15 (0.26)

1.09

[0.78-2.09]

 

 

n = 23

1.22 (0.16)

1.24

[0.82-1.57]

 

 

n = 23

1.21 (0.17)

1.23

[0.85-1.63]

 

 

n = 23

1.22 (0.15)

1.23

[0.87-1.55]

 

 

n = 23

1.26 (0.31)

1.2

[0.8-2.02]

 

 

n = 23

1.37 (0.26)

1.31

[1.08-2.08]

 

 

n = 23

1.41 (0.28)

1.32

[1.06-2.26]

 

Group

4

 

n = 20

0.94 (0.18)

0.93

[0.64-1.24]

 

 

n = 20

1.04 (0.18)

1.05

[0.8-1.45]

 

n = 20

1.26 (0.23)

1.25

[0.85-1.76]

 

 

n = 20

1.25 (0.23)

1.22

[0.8-1.75]

 

 

n = 20

1.24 (0.24)

1.24

[0.83-1.76]

 

 

n = 20

1.25 (0.28)

1.21

[0.88-1.84]

 

 

n = 20

1.36 (0.29)

1.29

[0.96-1.78]

 

 

n = 20

1.36 (0.28)

1.34

[0.94-1.8]

 

Group

5

 

n = 21

1.01 (0.15)

1.02

[0.77-1.3]

 

 

n = 21

1.16 (0.26)

1.13

[0.81-2.13]

 

 

n = 21

1.27 (0.2)

1.26

[0.92-1.69]

 

 

n = 21

1.29 (0.2)

1.24

[0.92-1.63]

 

 

n = 20

1.27 (0.2)

1.25

[0.89-1.69]

 

 

n = 21

1.28 (0.22)

1.26

[0.91-1.79]

 

 

n = 21

1.37 (0.26)

1.28

[1.11-2.27]

 

 

n = 21

1.39 (0.23)

1.35

[1.14-2.23]

 

Legend to Web Table 8. Values are presented as follows: within each cell the top row in the number of patients, the second row is the Mean (Standard Deviation), the third row is the Median and the bottom row is the range. There were no significant differences among the five groups (Repeated measure ANOVA) and there was no group versus time interaction .


Web Table 9. Episodes of arterial hypotension, hypertension, bradycardia and tachycardia that occurred in the operation room.

 

 

Group 1

n = 21

Group 2

n = 22

Group 3

n = 23

Group 4

n = 21

Group 5

n = 23

Total

n = 110

P value

 

Hypotension

Number of patients (%)

11 (52 %)

14 (64 %)

16 (70 %)

18 (86 %)

16 (70 %)

75 (68 %)

0.22

 

 

0.74

 

Number of episodes per patient

3 (3)

2

[1-10]

2.8 (1.4)

3

[1-5]

3.1 (2.2)

2.5

[1-8]

2.4 (1.9)

2

[1-9]

2.4 (1.5)

2

[1-6]

2.7 (2)

2

[1-10]

 

Hypertension

Number of patients (%)

14 (67 %)

16 (73 %)

14 (61 %)

8 (38 %)

11 (48 %)

63 (57 %)

0.14

 

 

0.51

 

Number of episodes per patient

2.9 (2)

2

[1-8]

2.1 (1.6)

2

[1-7]

1.8 (0.8)

2

[1-3]

2.3 (1.4)

2

[1-4]

2 (0.9)

2

[1-3]

2.2 (1.5)

2

[1-8]

 

Bradycardia

Number of patients (%)

2 (10 %)

2 (9 %)

4 (17 %)

1 (5 %)

3 (13 %)

12 (11 %)

0.79

 

 

0.35

 

Number of episodes per patient

2 (1.4)

2

[1-3]

1.5 (0.7)

1.5

[1-2]

1 (0)

1 (0)

1 (0)

1.3 (0.6)

1

[1-3]

 

Tachycardia

Number of patients (%)

1 (5 %)

0

1 (4 %)

4 (19 %)

0

6 (5 %)

0.03

 

 

0.33

 

 

Number of episodes per patient

2 (0)

 

 

1 (0)

1.3 (0.5)

1

[1-2]

 

1.3 (0.5)

1

[1-2]

Legend to Web Table 9. The numbers of episodes per patient are presented as follows. The top row is the mean (Standard Deviation) number of episodes; the middle row is the median and the lower row is the range. If only one row is present within a cell it represents the mean (Standard Deviation). There were no significant differences among the five groups for any hemodynamic event. A similar analysis was performed from induction of anesthesia to skin incision and there were no statistically significant differences among the five groups.


 

Web Table 10. Cardiovascular drugs requirement during anesthesia

 

 

Cardiovascular drugs

Group 1

n = 21

Group 2

n = 22

Group 3

n = 23

Group 4

n = 21

Group 5

n = 23

P value

Ephedrine

Number of patients (%)

10 (48 %)

12 (54 %)

12 (52 %)

13 (62 %)

14 (61 %)

 

 

0.84

Number of bolus//patient

1.1 (1.9)

0

[0-7]

1.2 (1.3)

1

[0-4]

1.2 (1.7)

1

[0-6]

1.2 (1.3)

1

[0-4]

1.5 (1.8)

1

[0-7]

Cumulative dose (mg)

 

13.9 (8.9)

12

[3-30]

11.8 (7.9)

12

[3-27]

12.7 (8.6)

10.5

[3-30]

9.69 (4.8)

9

[3-18]

18 (14)

13.5

[3-45]

0.64

Phenylephrine

Number of patients (%)

3 (14 %)

4 (18 %)

6 (26 %)

6 (29 %)

5 (22 %)

 

 

0.68

Number of bolus//patient

0.3 (1.1)

0

[0-5]

0.5 (1.4)

0

[0-5]

0.8 (1.9)

0

[0-8]

0.9 (2.1)

0

[0-9]

0.2 (0.4)

0

[0-1]

Cumulative dose (g)

233 (230)

100

[100-500]

391 (258)

475

[15-600]

590 (387)

625

[144-1000]

408 (453)

275

[50-1300]

103 (96)

50

[16-250]

0.17

Nicardipine

Number of patients (%)

14 (67 %)

16 (73 %)

14 (61 %)

8 (38 %)

11 (48 %)

 

 

0.15

Number of bolus//patient

2 (2.2)

2

[0-8]

1.5 (1.7)

1

[0-7]

1.1 (1.1)

1

[0-3]

0.9 (1.4)

0

[0-4]

1 (1.2)

0

[0-3]

Cumulative dose (mg)

3.86 (4.4)

2.25

[0.5-15.5]

3.21 (5.8)

1.5

[0.5-24.5]

1.21 (0.7)

1

[0.5-2.5]

1.56 (1.1)

1.75

[0.5-3.5]

3.27 (5.8)

1

[0.5-20.5]

0.46

Atropine

Number of patients (%)

2 (10 %)

2 (9 %)

4 (17 %)

0

2 (23 %)

 

 

0.41

Number of bolus//patient

0.1 (0.3)

0

[0-1]

0.1 (0.5)

0

[0-2]

0.2 (0.4)

0

[0-1]

 

0.1 (0.3)

0

[0-1]

Cumulative dose(mg)

1 (0)

1.25 (1.1)

1.25

[0.5-2]

0.75 (0.3)

0.75

[0.5-1]

 

1.25 (1.1)

1.25

[0.5-2]

0.83

Esmolol

Number of patients (%)

1 (5 %)

0

0

4 (19 %)

0

 

 

NS

Number of bolus//patient

0.1 (0.4)

0

[0-2]

 

 

 

0.2 (0.5)

0

[0-2]

 

Cumulative dose (mg)

40 (0)

 

 

26.2 (7.5)

25

[20-35]

 

0.14

 


Legend to Web Table 10. Values are presented as follows: within each cell the top row is the Mean (Standard deviation), the second row is the median value and the bottom row is the range. If only one row is present within a cell it represents the mean (Standard Deviation). There were no significant differences among the five groups for any of the cardiovascular drugs (percentage of patients, number of bolus injections or cumulative doses).